ACHEMS 2019
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SPLTRAK Abstract Submission
Anticipation Induces a Phase Shift of Low Frequency Oscillations in Human Piriform Cortex
Ghazaleh Arabkheradmand1, Guangyu Zhou1, Heidi Jiang1, Jay A Gottfried2, Joshua Rosenow1, Jessica Templer1, Gregory Lane1, Christina Zelano1
1Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
2Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

Sensory attention most commonly involves anticipation, which occurs prior to the arrival of a stimulus. Anticipatory states prime the brain for the coming perceptual task. Despite that fact that understanding of the neural signatures of anticipatory states is critical for understanding attention, most research on attention has focused on neural responses, which occur after the arrival of a stimulus. Thus, neural mechanisms underlying anticipatory states are not well understood. In this study, we used intracranial EEG recordings in human subjects performing an olfactory attention task to study anticipatory attention in the human brain.We investigated the spectrotemporal properties of attentional neural signatures during the time prior to stimulus delivery in both attended and unattended conditions. We found that anticipation of olfactory stimuli evokes low frequency (0-2Hz) phase coherence in human piriform cortex. This pre-stimulus phase coherence is correlates with both post-stimulus duration of inhale and post-stimulus odor-induced response magnitudes in piriform cortex. These correlations suggest that anticipatory states effect both odor sampling behavior and odor coding. Together these findings suggest that human piriform cortex carries essential attentional neural signatures prior to any physical contact with the stimuli.