ACHEMS 2019
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SPLTRAK Abstract Submission
Alzheimer's Disease & olfaction: preliminary results towards an early diagnosis
Rayane Zahal1, Dominique Petit1, Nadia Gosselin1, Julie Carrier1, Johannes Frasnelli1,2
1University of Montreal, Montreal, QC, Canada
2Université du Québec à Trois-Rivière, Trois-Rivière, QC, Canada

Alzheimer’s Disease (AD) is a neurodegenerative disease that affects cognitive function and behavior. It is the most frequent type of dementia among old people. Olfactory impairment appears many years before cognitive symptoms in AD patients, but its exact manifestation is still unclear. AD is a continuum with three distinct stages: preclinical, Mild Cognitive Impairment (MCI) and dementia.The goal of this study is to define specific patterns of olfactory impairment in the MCI phase. A better understanding of AD would bring us closer to developing therapeutic approaches to stop or slow down its progression in early stages. Five different olfactory tasks (odor identification, discrimination, recognition, threshold, and a cognitive modulation task to assess the impact of label on odor perception) are administered to three groups 1) amnestic MCI patients; 2) non-amnestic MCI patients; 3) controls Neuropsychological assessment include: memory and learning; language; attention and executive function; and visuospatial functions. Participants are followed up after 1.5 year. Three hypotheses shape this study: 1) Healthy participants have a better performance in olfactory tasks compared to MCI patients. 2) Non-amnestic MCI patients perform better than amnestic MCI patients in odor identification and recognition. 3) Participants who demonstrate impairment in odor recognition and identification tasks in T1, show a significantly greater cognitive decline/ conversion rate in T2. Testing and data acquisition are ongoing and preliminary results are presented.