ACHEMS 2019
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SPLTRAK Abstract Submission
Comprehensive modeling analysis of the role of cortical projections to olfactory bulb 
Christiane Linster1 & Leslie Kay2
1Dept. of Neurobiology and Behavior, Cornell University , Ithaca, NY, United States
2Department of Psychology Institute for Mind and Biology The University of Chicago, Chicago, IL, United States

Olfactory bulb networks integrate sensory information conveyed by sensory neurons with “internal” information conveyed by cortical and neuromodulatory areas. The role of neuromodulatory inputs to the OB has been widely studied experimentally and computationally and coherent ideas about their function exist. In contrast, information conveyed by cortical areas to the OB is sparse but increasing due to new experimental techniques. We here use our fully developed OB-cortex model to systematically investigate the computational impact of cortical to bulbar projections. We include known details of this projection such as target neurons, transmitter released and receptors and investigate unknown parameters such as the distribution of these projections, ratios of inputs to different cell types, timing of inputs with respect to bulbar dynamics. Our model shows that cortical inputs can have strong effects on bulbar signal to noise ratio, bulbar dynamics and bulbar odor representations. These effects depend strongly on cortical dynamics and activation, with cortex receiving olfactory as well as contextual inputs. In addition, when cortical neurons represent contextual inputs, behavioral salience or previously learned odorants, bulbar representations can be strongly modulated by previous experience. The tone and degree of influence cortical inputs have on bulbar processing can be set by learning, network state and previous experience. Funded by DARPA HR0011-18-2-0024