ACHEMS 2019
Search
SPLTRAK Abstract Submission
Defining the functions of olfactory bulb processing via comparison of input and output: adaptation
Douglas A Storace1,2 & Lawrence B Cohen2,3
1Florida State University, Tallahassee, FL, United States
2Yale University, New Haven, CT, United States
3KIST, Seoul, Korea

Humans and other animals exhibit adaptation to odorants. It remains unclear whether the olfactory bulb, the brain structure that mediates the first stage of olfactory information processing, participates in generating this perceptual adaptation. Olfactory bulb glomeruli are regions of neuropil that contain input and output processes; olfactory receptor neuron nerve terminals (input) and mitral/tufted cell apical dendrites (output). Differences between the input and output of a brain region define the function(s) carried out by that region. We compared the activity signals from the input and output to repeated odor stimulation across a range of odorant concentrations. Repeated odor stimulation of the same concentration resulted in a decline in the output maps, while the input remained relatively stable. These results suggest that the mammalian olfactory bulb may participate in the perception of adaptation. This approach may be useful for understanding the role of the olfactory bulb in other olfactory perceptions, and should also be useful for determining the input-output transformation in other regions of the mammalian brain.